Vaccines
Vaccines
COVID-19 vaccines:
For information about COVID-19 vaccines, see
COVID-19 vaccination
.
About vaccines
Vaccines are clever, they train our bodies into building immunity against
infectious diseases
, without causing the illness.
Usually, a dead or weakened version of the disease-causing germ (bacteria or virus) is introduced to our
immune system
. In some cases, inactivated toxins produced by the germ are used in the vaccine to develop immunity (for example,
diphtheria
and
tetanus
vaccines). We call these antigens, and they are the most important ingredient of all vaccines. Alternatively, mRNA vaccines instruct our cells to stimulate an immune response.
Once we’ve been vaccinated, if our immune system encounters the ‘real’ disease-causing germ, it responds quickly and creates antibodies and memory cells to give the body protection.
Immunisation (vaccination)
is the most effective preventative measure against serious diseases. Some vaccines offer lifelong immunity. In other cases,
‘catch-ups’ or booster shots
are needed.
When were vaccines developed?
Vaccines are not new – immunisation techniques were pioneered over 200 years ago, when
smallpox
was a feared and deadly disease. An eighteenth-century doctor named Edward Jenner noted that workers on farms who contracted the mild cowpox disease were immune to smallpox.
Jenner guessed that the germ responsible for cowpox was similar enough to the smallpox germ to ‘train’ the immune system to defeat both diseases. He was correct. Immunisation in Australia today relies on similar principles.
How do vaccines work?
Our immune system is made up of special cells and chemicals (called antibodies) that fight infection. We gain immunity against diseases either naturally (by catching an illness), or through immunisation.
Vaccines are made up of a modified version of a disease-causing germ or toxin (known as ‘antigens’). Alternatively mRNA vaccines instruct our cells to stimulate an immune response. Vaccines are usually given by injection or a small drink that contains the vaccine.
The immune system responds to the weakened, partial or dead germ or inactivated toxin (antigen) as if it was a fully-fledged germ, and makes antibodies to destroy it. These antibodies are made without us catching the illness.
How do vaccines help our immunity?
Our immune system is like a library – it stores information about every germ ever defeated. We sometimes call this immunological memory.
Some antibodies remain ‘on patrol’ in our bloodstream. So if we ever encounter the real germ in the future, our immune system can quickly trigger the memory cells and produce antibodies to defeat it. And this often occurs before we experience any symptoms of illness.
Each vaccine is designed according to how the specific germs make us sick. For example,
measles
is the result of the body’s reaction to the whole virus and so the vaccine contains a weakened form of the virus. On the other hand,
tetanus
is caused by the body’s reaction to the toxin produced by the tetanus bacteria and so the vaccine contains inactivated tetanus toxin.
What is in vaccines?
Depending on the infection, ingredients in vaccines can vary. They may also change from year to year as new strains of viruses (such as the
flu
) appear. Some vaccines may contain a small dose of:
a live (but weakened) germ
dead germs
small parts of germs (for example, a molecule from the surface of a germ)
inactivated toxins produced by bacteria
antibiotics or preservatives to stop the vaccine from becoming contaminated or going off
diluents (such as sterile water or saline).
Alternatively mRNA vaccines teach our cells how to make a protein that stimulates an immune response.
Australia has strict rules on vaccine safety. Before a vaccine is registered by the
Therapeutic Goods Administration
(TGA)
External Link
and made available to the public it goes through rigorous testing. And, even when it is used, it is constantly monitored for safety and effectiveness.
How are new vaccines developed?
It can take a long time to develop a new vaccine. Vaccines go through many phases of development – including research, discovery, pre-clinical testing, clinical testing and regulatory approval. Once the vaccine is approved, the vaccine is then manufactured and shipped to where it’s needed.
In certain circumstances, increased resources, concurrent clinical trials, and funding can fast-track development, such as in the case of the
COVID-19 vaccination
.
After vaccines are introduced into immunisation schedules, they are closely monitored through trials and surveillance to see if they are effective and safe. In Australia, there are regional and national surveillance systems actively looking for any adverse events following immunisation. This is necessary, as sometimes unexpected side effects occur after vaccines are registered for use.
Some vaccines, such as the
flu
, need to be updated every year to respond to changing infection strains and conditions. For these updates, the process is compressed to ensure the vaccine is available as needed.
Are vaccines safe?
Millions of people – many of them babies and young children – are immunised every year, with no
side effects
. Vaccines are much safer than getting sick from a disease. Diseases that can be prevented by vaccines can cause lifelong complications or death – even in normally healthy people.
From time to time, the safety of vaccines has been questioned. Most reactions are mild and usually last one to 2 days. Like any other medication, vaccines carry a small degree of risk, but serious side effects are rare.
The risk of serious side effects must be weighed against the risk of the disease. For example, there is a small risk of developing the rare condition known as
idiopathic thrombocytopenic purpura (ITP)
after the
measles, mumps, rubella and varicella (MMRV) vaccine and the measles, mumps and rubella (MMR) vaccine
. However, the risk of developing ITP with
measles
itself is more than 10 times greater than the risk associated with the vaccine.
How successful are vaccines?
Vaccination is the most effective preventative measure against infectious diseases. Most vaccine-preventable illnesses are highly contagious, spread quickly and can cause severe complications which may impact on our quality of life.
Vaccines give us immunity without us getting sick. They also protect vulnerable people in our community who cannot be immunised – such as very young children or those who are too sick.
When enough people in the community are vaccinated, the spread of a disease slows down or stops completely. So as long as enough people are vaccinated, diseases will not spread. We call this herd immunity or community immunity. The percentage of people who need to be immune in order to achieve herd immunity varies with each disease. For example:
Measles, mumps, rubella
– 95 out of every 100 people vaccinated will be completely immune.
Whooping cough
– about 85 out of every 100 people vaccinated will be completely immune.
How long does it take for a vaccine to work?
When we receive a vaccine, our immune system gets to work immediately to create antibodies and memory cells to fight the infection. On average, an immune response will take around 7 to 21 days.
However, the duration of immunity can depend on a number of factors, such as the nature of vaccine, the timing of dosages, our age, and whether we have had an infection naturally.
To be protected from vaccine-preventable diseases, make sure to stick to the
recommended
schedules
External Link
and keep your immunisations up to date.
Which vaccines do we need?
Vaccines not only protect us, but vulnerable people in our community (such as the young, the elderly, or those with weakened immunity).
The vaccines we may need are determined by our health, age, lifestyle and occupation. Together, these factors are known as HALO.
HALO is defined as:
Health
– some people may benefit from additional or more frequent immunisations due to health factors. For example,
pregnant women
,
premature babies
, or those with conditions (such as
asthma
,
diabetes
,
HIV
and disorders of the
heart
,
lungs
,
spleen
or
kidneys
).
Age
– at certain ages, we are more vulnerable to some illnesses. Such as in:
childhood
, in
secondary school
and when we are
older
.
Lifestyle
– some lifestyle choices can put us or the community at risk, such as
overseas travel
, moving to Australia, becoming a new
parent
,
sexual activity
,
smoking
, or
playing contact sport
.
Occupation
– some jobs have a higher risk of exposure to
infections
. Such as those who work in hospitals, childcare and emergency services.
Check your immunisation HALO using the Immunisation for Life infographic.
Immunisation for Life infographic (PDF)
376.29 KB
Remember, if you are not sure about what vaccines you need, talk to your GP (doctor). If you find you are not up to date with your vaccinations, your GP will tell you about
catch-ups and boosters
.
Australia’s National Immunisation Program Schedule
The
National Immunisation Program (NIP)
Schedule
External Link
sets out recommended immunisations for infants, children, older people and other people at risk, such as Aboriginal and Torres Strait Islander people. Most recommended vaccines are available at no cost to these groups.
If you need further information, talk to your
GP (doctor)
or
immunisation provider
.
Where to get help
In an emergency, always call triple zero (000)
Your
GP (doctor)
Your local council immunisation service – visit
Know Your
Council
External Link
Maternal and Child Health Line
Tel.
13 22 29
(24 hours, 7 days)
Nurse-on-Call
Tel.
1300 60 60 24
– for expert health information and advice (24 hours, 7 days)
Immunisation Unit, Department of
Health
External Link
, Victorian Government Email:
immunisation@health.vic.gov.au
National Immunisation Information
Line
External Link
Tel.
1800 671 811
Australian Immunisation
Register
External Link
Tel.
1800 653 809
Pharmacist
SAEFVIC
External Link
Tel.
1300 882 924
(select option 1)
Coronavirus (COVID-19) Victoria